Forum OpenACS Q&A: Re: OpenACS on Debian pros and cons...
Oh yeah, if it was up to me, I'd use Debian for everything, barring some much more compelling reasons than "Oracle Corp. says to use Red Hat". Like say, running Linux on an embedded microcontroller that's just too small for Debian, that sort of thing. :)
Of course, if you have multiple systems you would only do this once and then move the files over.
You would not lose data or configuration information, but would have to reboot.