Not to be reduntant, but I'll add another 'Aye' vote.
I'm in the process of customizing the ACS to act (initally) as a knowledge base for my department. I often get the "now what?" feeling when I'm looking around at all the modules available.
In a nutshell, my approach is going to be to get a couple of modules working and then get them "live", and take it from there. This will also involve putting in the infrastructure of users, web server, etc.
One key area that I didn't really think about when I started out doing this (and I know this might sound stupid...), is the home/start page. The basic 'please log in/register' screen obviously isn't going to cut it.