I can't see why not. I'm fairly positive that the fotonotes implementation uses image maps with a javascript tooltip library. The tooltip isn't an IE tooltip, which are limited to a single line text box. The javascript tooltip is rendered using CSS, and you can even insert HTML and images into the javascript tooltip.
I'm not sure how you create a fotonote, in that how does one specify where a note should be placed on an image? Is this left to the web developer to code? Or is there some sort of functionality that lets the user do this from a UI?
