In my opinion, current client side javascript environments are something too complex and hardboiling to be encapsulated in a package that would fit the needs of everybody.
Of course we could opt for including some of the less intrusive ones into specific UI features in OpenACS. I refer to "light" frameworks as JQuery or such.
However we choose, I fear this "marriage" could abruptly be broken on the next change of direction for web technologies, and would of course mean more work from the community to keep pace with framework development. A real example of this is Ajax Filestorage, build on ExtJS 2 if I recall correctly, and now quite useless, until someone finds time and will to rework it.
From a platform point of view I think we should focus on server side, either by producing plain text, markups/XML or JSON from data, as OpenACS is really good at it and leave fancy client side tecnology to the taste and needs of the single.
Antonio